945667-22-1 Usage
Uses
Used in Pharmaceutical Industry:
Saxagliptin hydrate is used as an antidiabetic drug for the treatment of type 2 diabetes. It works by inhibiting the DPP-4 enzyme, which is responsible for the degradation of GLP-1, a hormone that helps regulate blood glucose levels. By increasing the levels of active GLP-1, saxagliptin hydrate helps improve glycemic control and reduce blood sugar levels in patients with type 2 diabetes.
Used in Drug Metabolism Studies:
Saxagliptin hydrate is used in research to study the role of cytochrome P450 enzymes, specifically CYP3A4/5, in drug metabolism. Since metabolism of saxagliptin is primarily mediated by these enzymes, it serves as a useful model for understanding drug interactions and potential side effects when other medications are administered concurrently.
Used in Clinical Trials and Research:
Saxagliptin hydrate is used in clinical trials and research studies to evaluate its efficacy and safety in the treatment of type 2 diabetes. These studies help to determine the optimal dosage, potential side effects, and long-term benefits of using saxagliptin hydrate as a therapeutic intervention for diabetes management.
Used in Drug Interaction Studies:
Saxagliptin hydrate is used in studies to investigate potential drug interactions with other medications, particularly those that are strong inducers or inhibitors of cytochrome P450 enzymes. Understanding these interactions is crucial for ensuring patient safety and effective diabetes management.
Originator
Bristol-Myers-Squibb (US)
Check Digit Verification of cas no
The CAS Registry Mumber 945667-22-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,6,6 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 945667-22:
(8*9)+(7*4)+(6*5)+(5*6)+(4*6)+(3*7)+(2*2)+(1*2)=211
211 % 10 = 1
So 945667-22-1 is a valid CAS Registry Number.
InChI:InChI:1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2
945667-22-1Relevant academic research and scientific papers
A sand geleg sandbank salt and its preparation method
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Paragraph 0034; 0035, (2018/11/03)
The invention relates to a saxagliptin salt and a preparation method thereof. The saxagliptin salt has a structure represented by the formula II. Saxagliptin p-toluene sulfonate with a stable crystal form can be obtained through the salt-forming reactions between saxagliptin free alkali and p-toluene sulfonic acid under different solution systems. Stability researches show that saxagliptin p-toluene sulfonate has a better thermal stability than that of saxagliptin monohydrate and saxagliptin hydrochloride. Moreover, the preparation method of the saxagliptin salt is simple and is suitable for industrial production.
CRYSTAL FORMS OF SAXAGLIPTIN AND PROCESSES FOR PREPARING SAME
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Page/Page column 27-28, (2008/12/08)
Physical crystal structures of a compound of the formula (I): are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt containing 0.75 equivalent of H2O (form H0.75-3) and hydrochloric acid salt containing 2 equivalents of H2O (form H2-1), and hydrochloric acid salt Pattern P-5, preferably in substantially pure form, and other forms as described herein, pharmaceutical compositions containing structures of compound I or IA, processes for preparing same, intermediates used in preparing same, and methods of treating diseases such as diabetes using such structures.
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