945671-47-6Relevant academic research and scientific papers
Discovery of orally available integrin α5β1 antagonists
Zischinsky, Gunther,Osterkamp, Frank,Vossmeyer, Doerte,Zahn, Grit,Scharn, Dirk,Zwintscher, Ariane,Stragies, Roland
, p. 380 - 382 (2010)
Previous research within our laboratories identified the 3-hydroxypyrrolidine scaffold 1 as a new and selective integrin α5β1 inhibitor class which was designed for local administration. Herein the discovery of new orally available integrin α5β1 inhibitor scaffolds for potential systemic treatment is described.
