945732-91-2

Upstream product

• 875569-05-4 [(R)-1-(4-Ethyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)ethyl]-carbamic acid t-butyl ester 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 945732-94-5 (R)-1-(4-ethyl-5(4-methylphenylsulfanyl)-4H-[1,2,4]triazol-3-yl)-ethylamine 
• 945732-92-3 (1R)-1-(4-ethyl-5(4-fluorophenoxy)-4H-[1,2,4]-triazol-3-yl)ethylamine 
• 945733-13-1 (R)-1-[4-ethyl-5-(3-piperazin-1-yl-phenoxy)-4H-[1,2,4]triazol-3-yl]-ethylamine 
• 875569-06-5 (R)-1-(4-Ethyl-5-methanesulfonyl-4H-[1,2,4]triazol-3-yl)ethylamine 

Relevant academic research and scientific papers

TRIAZOLE DERIVATIVE

An object of the present invention is to provide a compound having an action of inhibiting binding between S1P and its receptor, Edg-1 (S1P1), and is useful as a pharmaceutical compound. A compound or a pharmaceutically acceptable salt thereof, which compound is represented by the formula below (where A represents an oxygen atom, a sulfur atom, a group represented by Formula -SO-, a group represented by Formula -SO2-, or the like, R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, or the like, R1A represents a hydrogen atom or the like, R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-6 carbon atoms, or the like, R3 represents an aryl group, R4 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms and optionally substituted with a carboxyl group, and R5 represents an alkyl group having 1-10 carbon atoms, a cycloalkyl group having 3-8 carbon atoms, an aryl group which is optionally substituted, or the like).

TRIAZOLE DERIVATIVE

A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between SIP and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. [where A represents a sulfur

TRIAZOLE DERIVATIVE

A compound represented by the formula (I) below or a pharmaceutically acceptable salt thereof has an effect of inhibiting binding between S1P and its receptor Edg-1(S1P1), and is useful as a pharmaceutical product. (I) (In the formula, A represents a sulfur atom, an oxygen atom, a formula -SO- or a formula -SO2-; R1 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms or the like; R2 represents an alkyl group having 1-6 carbon atoms, a cycloalkyl group having 3-8 carbon atoms or the like; R3 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4 represents a hydrogen atom, an alkyl group having 1-6 carbon atoms, a phenyl group or the like; R5 represents a hydrogen atom or an alkyl group having 1-6 carbon atoms; and R6 represents an alkyl group having 1-6 carbon atoms, a phenyl group or a substituted phenyl group.)