945764-80-7Relevant academic research and scientific papers
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
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Page/Page column 101, (2008/06/13)
Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.
CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
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Page/Page column 49-50, (2008/06/13)
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
