945828-50-2 Usage
Uses
Used in Pharmaceutical Industry:
AA 29504 is used as a cognitive enhancer for the treatment of cognitive deficits in schizophrenia patients. It activates extrasynaptic GABAA receptor activity, which has been shown to reverse recognition memory deficit in rat models of schizophrenia.
Used in Neuropharmacology Research:
AA 29504 is used as a research tool to study the role of extrasynaptic GABAA receptors in cognitive function and the pathophysiology of schizophrenia. It helps researchers to better understand the underlying mechanisms of cognitive deficits and develop novel therapeutic strategies for the treatment of schizophrenia and other related disorders.
references
[1]. k. hoestgaard-jensen, n.o. dalby, t.d. wolinsky, et al. pharmacological characterization of a novel positive modulator at α4β3δ-containing extrasynaptic gabaa receptors. neuropharmacology, 2010, 58:702-711.[2]. trine damgaard, niels plath, jo c. neill, et al. extrasynaptic gabaa receptor activation reverses recognition memory deficits in an animal model of schizophrenia. psychopharmacology, 2011, 214:403-413.[3]. henrik h. hansen, christina ebbesen, claus mathiesen, et al. the kcnq channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. journal of pharmacology and experimental therapeutics, 2006, 318(3): 1006–1019.
Check Digit Verification of cas no
The CAS Registry Mumber 945828-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,5,8,2 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 945828-50:
(8*9)+(7*4)+(6*5)+(5*8)+(4*2)+(3*8)+(2*5)+(1*0)=212
212 % 10 = 2
So 945828-50-2 is a valid CAS Registry Number.
