945847-77-8

Basic information

• Product Name: 6-(trifluoromethyl)-1,3-dihydro-2-benzofuran-1-ol
• Synonyms: 6-(trifluoromethyl)-1,3-dihydro-2-benzofuran-1-ol
• CAS NO: 945847-77-8
• Molecular Weight: 204.149
• Mol File: 945847-77-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(trifluoromethyl)-1,3-dihydro-2-benzofuran-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(trifluoromethyl)-1,3-dihydro-2-benzofuran-1-ol(945847-77-8)
• EPA Substance Registry System: 6-(trifluoromethyl)-1,3-dihydro-2-benzofuran-1-ol(945847-77-8)

Safety Data

• Hazardous Substances Data: 945847-77-8(Hazardous Substances Data)

Upstream product

• 13055-63-5 2-methyl-5-(trifluoromethyl)benzoic acid 

Relevant articles and documents

Squaramide-catalyzed asymmetric intramolecular oxa-michael reaction of α,β-unsaturated carbonyls containing benzyl alcohol: Construction of chiral 1-substituted phthalans

Organocatalytic enantioselective intramolecular oxa-Michael reactions of benzyl alcohol bearing α,β-unsaturated carbonyls as Michael acceptors are presented herein. Using cinchona squaramide-based organocatalyst, enones as well as α,βunsaturated esters containing benzyl alcohol provided their corresponding 1,3-dihydroisobenzofuranyl-1-methylene ketones and 1,3-dihydroisobenzofuranyl-1-methylene esters in excellent yields with high enantioselectivities. In addition, enantioenriched 1,3-dihydroisobenzofuranyl-1-methylene ketone could be obtained from the Wittig/oxa-Michael reaction cascade of 1,3-dihydro-2-benzofuran-1-ol.