945864-93-7Relevant academic research and scientific papers
Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors
Tang, Jun,Hamajima, Toshihiro,Nakano, Masato,Sato, Hideyuki,Dickerson, Scott H.,Lackey, Karen E.
, p. 4610 - 4614 (2008)
The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC50 = 2.5 nM) and the cellular assay (ICsub
Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors
-
Page/Page column 21, (2009/01/24)
The present invention provides pyrrolo pyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
