945865-04-3Relevant academic research and scientific papers
Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors
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Page/Page column 24, (2009/01/24)
The present invention provides pyrrolo pyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors
Tang, Jun,Hamajima, Toshihiro,Nakano, Masato,Sato, Hideyuki,Dickerson, Scott H.,Lackey, Karen E.
scheme or table, p. 4610 - 4614 (2009/04/08)
The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC50 = 2.5 nM) and the cellular assay (ICsub
