945865-09-8Relevant academic research and scientific papers
Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors
Tang, Jun,Hamajima, Toshihiro,Nakano, Masato,Sato, Hideyuki,Dickerson, Scott H.,Lackey, Karen E.
scheme or table, p. 4610 - 4614 (2009/04/08)
The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC50 = 2.5 nM) and the cellular assay (ICsub
