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2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)-, commonly known as methotrexate, is a medication and chemotherapy drug that plays a crucial role in treating various conditions, including cancer, autoimmune diseases, and ectopic pregnancy. It functions by disrupting the growth and spread of cancer cells within the body. Methotrexate is also effective in managing rheumatoid arthritis, psoriasis, and inflammatory bowel disease. Administered orally or through injection, it is classified as a high-risk medication due to its potential for severe side effects if not used correctly. Common side effects include nausea, vomiting, abdominal pain, and a decrease in blood cell counts.

94591-04-5

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94591-04-5 Usage

Uses

Used in Oncology:
2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)is used as a chemotherapy agent for the treatment of various types of cancer. It works by inhibiting the synthesis of DNA, RNA, and proteins, thereby preventing the proliferation and spread of cancer cells.
Used in Autoimmune Diseases:
In the field of rheumatology, 2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)is used as a disease-modifying antirheumatic drug (DMARD) for the management of rheumatoid arthritis. It helps to reduce inflammation and slow down the progression of joint damage.
Used in Dermatology:
2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)is used as an immunosuppressive agent in dermatology for the treatment of severe psoriasis. It helps to control the overactive immune response that leads to skin inflammation and scaling.
Used in Gastroenterology:
In the treatment of inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, 2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)is used as an immunosuppressive agent. It helps to reduce inflammation in the gastrointestinal tract and alleviate symptoms associated with these conditions.
Used in Obstetrics:
2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)is used as a medication for the treatment of ectopic pregnancy. It helps to terminate the abnormal pregnancy by inhibiting the growth of the trophoblast cells, which are essential for the development of the placenta.
Overall, 2,4,6(3H)-Pteridinetrione, 1,5-dihydro-1,3-dimethyl-7-(1-oxopropyl)-, or methotrexate, is a versatile medication with a wide range of applications across different medical fields. Its ability to interfere with the growth and spread of cells makes it an essential tool in the management of various conditions, from cancer to autoimmune diseases. However, due to its high-risk nature, it must be used with caution and under the supervision of a healthcare professional to minimize the risk of severe side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 94591-04-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,4,5,9 and 1 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 94591-04:
(7*9)+(6*4)+(5*5)+(4*9)+(3*1)+(2*0)+(1*4)=155
155 % 10 = 5
So 94591-04-5 is a valid CAS Registry Number.

94591-04-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Hydroxy-1,3-dimethyl-7-propionyllumazin

1.2 Other means of identification

Product number -
Other names 6-Hydroxy-1,3-dimethyl-7-propionyl-1H-pteridine-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:94591-04-5 SDS

94591-04-5Downstream Products

94591-04-5Relevant academic research and scientific papers

Pteridines, LXXIV. - Acylations of Lumazines by Radical Nucleophilic Substitution

Baur, Ralph,Kleiner, Erna,Pfleiderer, Wolfgang

, p. 1798 - 1814 (2007/10/02)

Lumazines are prone to radical nucleophilic substitutions and form with acyl radicals at the unsubstituted pyrazine moiety in a regioselective reaction 7-acyllumazines (12 - 21).Alkyl substituents in 7-position direct the entering acyl residue into the 6-

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