945921-07-3Relevant academic research and scientific papers
The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators
Tyrrell, Elizabeth,Tesfa, Kibur Hunie,Greenwood, Iain,Mann, Alistair
, p. 1237 - 1240 (2008)
A range of novel benzopyrans have been synthesised and biologically evaluated for KATP channel activity employing cromakalim 1 as a benchmark KATP channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K+ channel activity.
