94596-27-7

Basic information

• Product Name: Senkyunolide H
• Synonyms: Senkyunolide H;(3Z,6R,7S)-rel-3-Butylidene-4,5,6,7-tetrahydro-6,7-dihydroxy-1(3H)-isobenzofuranone
• CAS NO: 94596-27-7
• Molecular Formula: C₁₂H₁₆O₄
• Molecular Weight: 224.25300
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 94596-27-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 444.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.28
• Storage Temp.: 2-8°C
• PKA: 12.78±0.40(Predicted)
• CAS DataBase Reference: Senkyunolide H(CAS DataBase Reference)
• NIST Chemistry Reference: Senkyunolide H(94596-27-7)
• EPA Substance Registry System: Senkyunolide H(94596-27-7)

Safety Data

• Hazardous Substances Data: 94596-27-7(Hazardous Substances Data)

Usage

Uses

Senkyunolide H is a phthalide isolated from the rhizome of Ligusticum chuanxiong Hort. Senkyunolide H has been reported to have several pharmacological activities, including anti-?atherosclerotic, antiproliferative, and cytoprotective effects. senkyunolide H protects against MPP+-induced apoptosis via the ROS-mediated mitogen-activated protein kinase pathway in PC12 cells.

Upstream product

• 94530-85-5 senkyunolide-G 
• 81944-09-4 Z-ligustilide 

Relevant articles and documents

Metabolism of Chuanxiong Rhizoma decoction: Identification of the metabolites in WZS-miniature pig urine

Abstract Chuanxiong Rhizoma (CR), a well-known traditional Chinese medicine originated from the rhizome of Ligusticum chuanxiong Hort., was effective for treating various vascular diseases. To identify the metabolites of CR in vivo, the drug-containing urine samples of WZS-miniature pigs after orally administrated CR decoction were collected, after sequential column chromatography 17 metabolites (M1-M17) were isolated from the methanol extract of the urine samples. Their structures, including nine phthalides (M1-M9) and eight phenolic acids (M10-M17), were identified by spectroscopic means. Among them, 8 were new ones (M1-M6, M11-M12). On the basis of the structures of identified metabolites, seven original constituents, including 2 phthalides (senkyunolideI/H) and 5 phenolic acids (ferulic acid, isoferulic acid, caffeic acid, 3-hydroxycinnamoyl acid and 4-hydroxybenzonic acid) were deduced to be the major absorbed original constituents of CR in vivo. This is the first study on the metabolites of CR decoction in non-rodent animal (WZS-miniature pig), the results will give an insight into the metabolism profiles of phthalides and phenolic acids in CR decoction in vivo.

Components of Cnidium officinale makino: Occurrence of pregnenolone, coniferyl ferulate, and hydroxyphthalides

-