945965-72-0Relevant academic research and scientific papers
ALKENYLDIARYLMETHANES HAVING NITROGEN-CONTAINING CARBOXYLIC ACID DERIVATIVES
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, (2008/12/04)
Alkenydiarylmethane compounds are described. Such compounds are a class of non-nucleoside inhibitors of HIV-I reverse transcriptase, which may also be used as part of a combination therapy to treat HIV infection. Compounds described herein exhibit antivir
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems
Sakamoto, Takeshi,Cullen, Matthew D.,Hartman, Tracy L.,Watson, Karen M.,Buckheit, Robert W.,Pannecouque, Christophe,De Clercq, Erik,Cushman, Mark
, p. 3314 - 3321 (2008/02/09)
The alkenyldiarylmethanes (ADAMs) are a unique class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) that are capable of inhibiting HIV-1 reverse transcriptase (RT) through an allosteric mechanism. However, the potential usefulness of the ADAM
