945985-98-8

Basic information

• Product Name: N-[3,5-bis(trifluoroMethyl)phenyl]-N'-(9R)-cinchonan-9-yl-Urea
• Synonyms: N-[3,5-bis(trifluoroMethyl)phenyl]-N'-(9R)-cinchonan-9-yl-Urea
• CAS NO: 945985-98-8
• Molecular Weight: 548.531
• Mol File: 945985-98-8.mol

Chemical Properties

• CAS DataBase Reference: N-[3,5-bis(trifluoroMethyl)phenyl]-N'-(9R)-cinchonan-9-yl-Urea(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3,5-bis(trifluoroMethyl)phenyl]-N'-(9R)-cinchonan-9-yl-Urea(945985-98-8)
• EPA Substance Registry System: N-[3,5-bis(trifluoroMethyl)phenyl]-N'-(9R)-cinchonan-9-yl-Urea(945985-98-8)

Safety Data

• Hazardous Substances Data: 945985-98-8(Hazardous Substances Data)

Upstream product

• 16588-74-2 3,5-ditrifluoromethylisocyanate 
• 189309-11-3 (S)-quinolin-4-yl((1S,2R,4S,5R)-5-vinylquinuclidin-2-yl)methanamine 
• 118-10-5 Cinchonin 

Relevant articles and documents

Catalytic Asymmetric Intramolecular Bromolactonization of α,β-Unsaturated Ketones

Enantioselective bromolactonization by using an amino-urea catalyst to generate the important bromo-containing 3,4-dihydroisocoumarins is described. Excellent yields and good enantioselectivities could be achieved for various 3,4-dihydroisocoumarin compou

Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts

The enantioselective syntheses of axially chiral heterobiaryls were accomplished through the aromatic electrophilic halogenation of 3-(quinolin-8-yl)phenols with bifunctional organocatalysts that control the molecular conformations during successive halogenations. Axially chiral quinoline derivatives, which have rarely been synthesized in an enantioselective catalytic manner, were afforded in moderate-to-good enantioselectivities through bromination, and an analogous protocol also enabled enantioselective iodination. In addition, this catalytic reaction, which allows enantioselective control through the use of mono-ortho-substituted substrates, allowed the asymmetric synthesis of 8-arylquinoline derivatives bearing two different halogen groups in high enantioselectivities.

Asymmetric chroman synthesis via an intramolecular oxy-Michael addition by bifunctional organocatalysts

Cinchona-alkaloid-urea-based bifunctional organocatalysts facilitate the catalytic asymmetric synthesis of chroman derivatives via an intramolecular oxy-Michael addition reaction. Phenol derivatives bearing an easily available (E)-α,β-unsaturated ketone or a thioester moiety are useful substrates for the title transformation. This method represents a facile synthesis of various optically active 2-substituted chromans in high yield. The Royal Society of Chemistry.