945997-29-5Relevant academic research and scientific papers
Piperidine-based renin inhibitors: Upper chain optimization
Corminboeuf, Olivier,Bezenon, Olivier,Remeň, ?ubo?,Grisostomi, Corinna,Richard-Bildstein, Sylvia,Bur, Daniel,Prade, Lars,Strickner, Panja,Hess, Patrick,Fischli, Walter,Steiner, Beat,Treiber, Alexander
, p. 6291 - 6296 (2010)
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor wi
