946113-01-5

Basic information

• Product Name: C₁₃H₂₁NO₂
• Synonyms: C₁₃H₂₁NO₂
• CAS NO: 946113-01-5
• Molecular Weight: 223.315
• Mol File: 946113-01-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₃H₂₁NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₃H₂₁NO₂(946113-01-5)
• EPA Substance Registry System: C₁₃H₂₁NO₂(946113-01-5)

Safety Data

• Hazardous Substances Data: 946113-01-5(Hazardous Substances Data)

Upstream product

• 16015-07-9 4-Isopropyl-2-furaldehyde 
• 4276-09-9 (R)-2-amino-3-methylbutanol 

Downstream Products

• 473733-03-8 C₁₂H₂₁NO 
• 608537-89-9 C₁₁H₁₉NO 
• 608537-88-8 C₉H₁₅NO 
• 473733-02-7 (R)-1-(4-isopropylfuran-2-yl)propan-1-amine 

Relevant articles and documents

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists

A novel series of cyclobutenedione centered C(4)-alkyl substituted furanyl analogs was developed as potent CXCR2 and CXCR1 antagonists. Compound 16 exhibits potent inhibitory activities against IL-8 binding to the receptors (CXCR2 Ki = 1 nM, IC50 = 1.3 nM; CXCR1 Ki = 3 nM, IC50 = 7.3 nM), and demonstrates potent inhibition against both Gro-α and IL-8 induced hPMN migration (chemotaxis: CXCR2 IC50 = 0.5 nM, CXCR1 IC50 = 37 nM). In addition, 16 has shown good oral pharmacokinetic profiles in rat, mouse, monkey, and dog.