946127-54-4

Basic information

• Product Name: 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL
• Synonyms: 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL;(2-Chloro-3-fluoropyridin-4-yl)methanol;(2-Chloro-3-fluoropyridin-2-yl)methanol
• CAS NO: 946127-54-4
• Molecular Formula: C₆H₅ClFNO
• Molecular Weight: 161.56
• Mol File: 946127-54-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 263.684°C at 760 mmHg
• Flash Point: 113.272°C
• Appearance: /
• Density: 1.434g/cm³
• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL(946127-54-4)
• EPA Substance Registry System: 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL(946127-54-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 946127-54-4(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-fluoro-4-pyridinemethanol is a chemical compound with the molecular formula C6H5ClFNO. It is a colorless to light yellow liquid with a molecular weight of 159.57 g/mol. 2-CHLORO-3-FLUORO-4-PYRIDINEMETHANOL is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also a versatile building block for the production of various fluorinated compounds. 2-Chloro-3-fluoro-4-pyridinemethanol has applications in the pharmaceutical industry as a key intermediate in the synthesis of pharmaceutical drugs and is used in the development of antiviral, anticancer, and antifungal medications. Additionally, it is utilized in the production of insecticides, herbicides, and other agricultural chemicals.

InChI:InChI=1/C6H5ClFNO/c7-6-5(8)4(3-10)1-2-9-6/h1-2,10H,3H2

Upstream product

• 17282-04-1 2-chloro-3-fluoropyridine 
• 68-12-2 N,N-dimethyl-formamide 
• 628691-93-0 2-chloro-3-fluoro-pyridine-4-carboxylic acid 

Downstream Products

• 870063-62-0 3-fluoro-4-(aminomethyl)pyridine 
• 946127-56-6 dibenzylidene[4-(tert-butyldimethylsilyloxymethyl)-3-fluoropyridin-2-yl]amine 
• 946127-57-7 [2-(benzhydrylidene-amino)-3-fluoropyridin-4-yl]methanol 
• 946127-58-8 2-[2-(benzhydrylidene-amino)-3-fluoropyridin-4-ylmethyl]-3-oxo-butyric acid ethyl ester 
• 1548889-48-0 3-(2-amino-3-fluoropyridin-4-ylmethyl)-4-methyl-7-phenoxy-chromen-2-one 
• 1548889-68-4 3-[2-((N-methylsulfamoyl)amino)-3-fluoropyridin-4-ylmethyl]-4-methyl-7-phenoxychromen-2-one 

Relevant articles and documents

MEK INHIBITORS AND THERAPEUTIC USES THEREOF

The present disclosure provides compounds, compositions containing such compounds, and methods of designing, developing, producing and preparing compounds represented by general Formula (I), including pharmaceutically acceptable salts thereof or a synthetic intermediate thereof. The compounds act as MEK inhibitors and are capable of displaying one or more beneficial therapeutic effects, including treating cancer.

p27 PROTEIN INDUCER

The present invention provides a p27 protein inducing agent comprising a compound represented by general formula (11) below or pharmaceutically acceptable salt thereof as an active ingredient: wherein G 1 , G 2 , G 3 and G 8 are each independently selected from -N= etc., Ring G 6 is selected from divalent aryl etc., A is selected from amino etc., G 4 is selected from oxygen etc., G 5 is selected from oxygen etc., G 7 is selected from -CH 2 - etc., and R 2 is selected from C 1-6 alkyl etc.

INDOLE COMPOUNDS OR ANALOGUES THEREOF USEFUL FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION (AMD)

The present invention provides a compound of formula (I): a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.