946147-25-7

Basic information

• Product Name: 2-bromo-4-n-hexylaniline
• Synonyms: 2-bromo-4-n-hexylaniline
• CAS NO: 946147-25-7
• Molecular Weight: 256.186
• Mol File: 946147-25-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-4-n-hexylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4-n-hexylaniline(946147-25-7)
• EPA Substance Registry System: 2-bromo-4-n-hexylaniline(946147-25-7)

Safety Data

• Hazardous Substances Data: 946147-25-7(Hazardous Substances Data)

Upstream product

• 33228-45-4 4-hexylaniline 

Downstream Products

• 1261027-81-9 2-bromo-4-hexyl-1-iodobenzene> 
• 1261027-82-0 2-bromo-1-ethynyl-4-hexylbenzene 
• 1261027-83-1 1,4-bis(2-bromo-4-hexylphenyl)-diacetylene 
• 1395060-15-7 4-hexyl-2-vinylaniline 

Relevant articles and documents

Design, synthesis, and biological evaluation of novel transrepression- selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11- methylene-6 H-dibenz[ b, e ]azepin-6-one skeleton

To obtain novel transrepression-selective liver X receptor (LXR) ligands, we adopted a strategy of reducing the transactivational agonistic activity of the 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one derivative 10, which exhibits LXR-mediated transrepressional and transactivational activity. Structural modification of 10 based on the reported X-ray crystal structure of the LXR ligand-binding domain led to a series of compounds, of which almost all exhibited transrepressional activity at 1 or 10 μM but showed no transactivational activity even at 30 μM. Among the compounds obtained, 18 and 22 were confirmed to have LXR-dependent transrepressional activity by using peritoneal macrophages from wild-type and LXR-null mice. A newly developed fluorescence polarization assay indicated that they bind directly to LXRα. Next, further structural modification was performed with the guidance of docking simulations with LXRα, focusing on enhancing the binding of the ligands with LXRα through the introduction of substituents or heteroatom(s). Among the compounds synthesized, compound 48, bearing a hydroxyl group, showed potent, selective, and dose-dependent transrepressional activity.

High-performance organic field-effect transistors based on dihexyl-substituted dibenzo[d,d′]thieno[3,2-b;4,5-b′]dithiophene

A novel thienoacene compound, dihexyl-substituted dibenzo[d,d′] thieno[3,2-b;4,5-b′]dithiophene (C6-DBTDT), is developed as a p-type organic semiconductor for high-performance organic field-effect transistors. Insertion of an acceptor material at the cont