946147-99-5Relevant articles and documents
Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity
Nakagawa-Goto, Kyoko,Bastow, Kenneth F.,Chen, Tzu-Hsuan,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung
, p. 3297 - 3303 (2008)
Sixteen analogues (3-16, 33, and 48) of the unique flavonoid desmosdumotin B (1) were prepared and evaluated as in vitro inhibitors of the human KB cancer cell line and its MDR subclone, KB-VIN. 6,8,8-Triethyl analogues 10-13 showed enhanced KB-VIN select
Antitumor agents 283. Further elaboration of Desmosdumotin C analogs as potent antitumor agents: Activation of spindle assembly checkpoint as possible mode of action
Nakagawa-Goto, Kyoko,Wu, Pei-Chi,Bastow, Kenneth F.,Yang, Shuenn-Chen,Yu, Sung-Liang,Chen, Hsuan-Yu,Lin, Jau-Chen,Goto, Masuo,Morris-Natschke, Susan L.,Yang, Pan-Chyr,Lee, Kuo-Hsiung
scheme or table, p. 1816 - 1822 (2011/04/17)
In our ongoing study of the desmosdumotin C (1) series, twelve new analogues, 21-32, mainly with structural modifications in ring-A, were prepared and evaluated for in vitro antiproliferative activity against several human tumor cell lines. Among them, th
Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs
Nakagawa-Goto, Kyoko,Chen, Tzu-Hsuan,Peng, Chieh-Yu,Bastow, Kenneth F.,Wu, Jiu-Hong,Lee, Kuo-Hsiung
, p. 3354 - 3358 (2008/02/09)
Desmosdumotin C (1) and its analogs previously showed potent, selective in vitro anticancer activity. To explore structure-activity relationships of 1 and further increase potency and selectivity, 15 novel analogs (7-15 and 21-26) were synthesized and eva
