946249-99-6

Basic information

• Product Name: N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-4-methylbenzenesulfonamide
• Synonyms: N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-4-methylbenzenesulfonamide
• CAS NO: 946249-99-6
• Molecular Weight: 394.516
• Mol File: 946249-99-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-4-methylbenzenesulfonamide(946249-99-6)
• EPA Substance Registry System: N-(1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)-4-methylbenzenesulfonamide(946249-99-6)

Safety Data

• Hazardous Substances Data: 946249-99-6(Hazardous Substances Data)

Upstream product

• 927996-55-2 7-amino-1-(ethylsulfonyl)-1,2,3,4-tetrahydroquinoline 
• 98-59-9 p-toluenesulfonyl chloride 
• 30450-62-5 7-nitro-1,2,3,4-tetrahydro-quinoline 
• 1216970-05-6 1-(ethylsulfonyl)-7-nitro-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei

The high throughput screening of a library of over 87,000 drug-like compounds against the African sleeping sickness parasite resulted in the discovery of hits with a wide range of molecular diversity. We report here the medicinal chemistry development of one such hit, a tetrahydroisoquinoline disulfonamide, with the synthesis and testing of 26 derivatives against the trypanosome subspecies. Activities in the 2-4 μM range were revealed with a selectivity index suitable for further development.