946411-10-5Relevant articles and documents
Carbohydrate-based macrolides prepared via a convergent ring closing metathesis approach: In search for novel antibiotics
Ruttens, Bart,Blom, Petra,Van Hoof, Steven,Hubrecht, Idzi,Van Der Eycken, Johan,Sas, Benedikt,Van Hemel, Johan,Vandenkerckhove, Jan
, p. 5514 - 5522 (2007)
(Chemical Equation Presented) An efficient convergent approach has been developed for the construction of novel, nonnatural polysubstituted carbohydrate-based macrolides. A key step in the synthesis is the formation of the macrocyclic ring via a ring-closing metathesis reaction. The obtained macrolide analogues have been screened for biological activity against gram-positive and gram-negative bacteria, yeasts, and molds.