946425-33-8Relevant articles and documents
One-pot green synthesis for pyrimido[4,5-d]pyrimidine derivatives
Kidwai, Mazaahir,Singhal, Kavita,Kukreja, Shuchi
, p. 732 - 736 (2007)
Water has been used efficiently as a solvent for the reaction of barbituric acid, aldehyde and urea or thiourea to yield pyrimido[4,5-d]pyrimidines. This environmentally benign procedure leads to high yields of products of greater purity in a single step using water.
Facile and simple synthesis of pyrimido[4,5-d]pyrimidinones and pyrano[2,3-d]pyrimidinones catalyzed by nano-sized NS-C4(DABCO-SO3H)2·4Cl
Goli-Jolodar, Omid,Shirini, Farhad
, p. 1235 - 1241 (2017/05/15)
In this work, 4,4′-(butane-1,4-diyl)bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium)tetrachloride (NS-C4(DABCO-SO3H)2·4Cl), a newly reported nano-sized Br?nsted acid catalyst is used for the effective synthesis of pyrimido[4,5-d]pyrimidinones and pyrano[2,3-d]pyrimidinones derivatives. The products were formed under mild and environmentally friendly conditions in excellent yields over very short reaction times. Using green solvent and simple methodologies, no side reactions and use of inexpensive catalyst with lower loading are other advantages of this work.
Dual acidic ionic liquid immobilized on α-Fe2O3-MCM-41 magnetic mesoporous materials as the hybrid acidic nanocatalyst for the synthesis of pyrimido[4,5-d]pyrimidine derivatives
Rostamizadeh, Shahnaz,Nojavan, Masoomeh,Aryan, Reza,Azad, Mohammad
, p. 1772 - 1783 (2015/02/19)
Magnetic α-Fe2O3-MCM-41 mesoporous material functionalized by dual acidic ionic liquid (DAIL) was prepared through a two-step approach as a novel powerful acidic catalyst which provides high ionic media for reactions, by means of post-surface grafting of the mesochannels of α-Fe2O3-MCM-41 materials with 3-sul-fobutyl- 1-(3-propyltrimethoxysilane)imidazolium hydrogen sulfate as DAIL. Mesoporous MCM-41 was simply packed on the surface of ferric oxide nanoparticles and DAIL was efficiently incorporated into the mesochannels of MCM-41 generating Lewis and Br?nsted acidic sites. The catalyst was characterized by FT-IR, X-ray powder diffraction, HRTEM, vibrating sample magnetometer, X-ray energy diffraction spectra, thermogravimetric and differential thermal analyses, and N2 adsorption-desorption measurements. The synthesized hybrid acidic MCM-41 showed good catalytic performance in the one-pot synthesis of pyrimido[4,5-d]pyrimidine derivatives using 6-aminouracil, aldehyde, and urea or thiourea under solvent free conditions. Moreover, it was proved that under this condition, the use of such a hybrid material as a catalyst plays the role of rendering the reactions while neither the α-Fe2O3-MCM-41 nor the 3-methyl-1-(4-sulfonic acid)butylimidazolium hydrogen sulfate were able to promote this reaction.