94644-47-0

Usage

Uses

Used in Pharmaceutical Synthesis:
2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with antitumor and antimalarial properties. Its incorporation into drug molecules can enhance their therapeutic effects and target specific biological pathways.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is utilized as a precursor in the creation of compounds with pesticidal or herbicidal activities. Its chemical structure allows for the design of novel agrochemicals that can address resistance issues and improve crop protection.
Used in Medicinal Chemistry Research:
2-CHLORO-6,7-DIMETHOXYQUINAZOLINE serves as a valuable compound in medicinal chemistry research, where it is explored for its potential to be a building block for biologically active molecules. Researchers use its versatile structure to create new compounds that can target various diseases and conditions, expanding the scope of available treatments.
Used in Antimalarial Applications:
2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is studied for its potential as an antimalarial agent, where it could contribute to the development of new treatments for malaria. Its unique structure may offer a new approach to combating the Plasmodium parasites responsible for this disease.
Used in Antitumor Applications:
As an antitumor agent, 2-CHLORO-6,7-DIMETHOXYQUINAZOLINE is investigated for its capacity to inhibit tumor growth and progression. Its incorporation into pharmaceutical compounds may lead to the development of new cancer therapies that are more effective and have fewer side effects.

InChI:InChI=1/C10H9ClN2O2/c1-14-8-3-6-5-12-10(11)13-7(6)4-9(8)15-2/h3-5H,1-2H3

Upstream product

• 27631-29-4 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 

Downstream Products

• 1036743-33-5 4-(6,7-dimethoxyquinazolin-2-ylamino)benzenesulfonamide 
• 253191-99-0 4-[1-(6,7-Dimethoxyquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 

Relevant academic research and scientific papers

Search for the pharmacophore in prazosin for Transport-P

Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.

Antibacterial quinazoline compounds

Provided are compounds of formula (I) wherein X, Y and Z are independently CH or N; n is 0 or 1; R1 is selected from OH, alkoxy, aryloxy, aralkyloxy and guanidinyl; R2 and R3 are independently selected from H, halogen, amino, hydroxyl, nitro, cyano and carboxyl; R4 is H, alkyl or acyl; R5 is selected from H, hydroxyl, halogen, nitro, alkyl, alkoxy, amino, cyclic amino, alkylamino, arylamino and aralkylamino wherein the alkyl, aryl and cyclic moieties are optionally substituted; R6 and R7 are independently selected from H, alkyl, alkoxy, halogen and amino; and R8 and R9 are independently selected from H, C1-4 alkyl, alkoxy, acyl, acyloxy, alkoxycarbonyl, hydroxyl, halogen, amino and carboxyl. The compounds have therapeutic or prophylactic use for treating bacterial infection in mammals.

Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents

High-throughput screening of in-house compound libraries led to the discovery of a novel antibacterial agent, compound 1 (MIC: 12-25 μM against S. pyogenes). In an effort to improve the activity of this active compound, a series of 2-substituted quinazolines was synthesized and evaluated in several antibacterial assays. One such compound (22) displayed improved broad- spectrum antibacterial activity against a variety of bacterial strains. This molecule also inhibited transcription/translation of bacterial RNA, suggesting a mechanism for its antibiotic effects. Structure-activity relationship studies of 22 led to the synthesis of another 24 compounds. Although some of these molecules were found to be active in bacterial growth assays, none were as potent as 22. Compound 22 was tested for its ability to cure a systemic K. pneumonia infection in the mouse and displayed moderate effects compared with a control antibiotic, gentamycin.