94644-50-5Relevant academic research and scientific papers
Search for the pharmacophore in prazosin for Transport-P
Zunszain, Patricia A.,Federico, Cesare,Sechi, Mario,Al-Damluji, Saad,Ganellin, C. Robin
, p. 3681 - 3689 (2005)
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
