946489-95-8Relevant academic research and scientific papers
Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors
Boschelli, Diane H.,Wang, Daniel,Wang, Yan,Wu, Biqi,Honores, Erick E.,Barrios Sosa, Ana Carolina,Chaudhary, Inder,Golas, Jennifer,Lucas, Judy,Boschelli, Frank
scheme or table, p. 2924 - 2927 (2010/07/04)
The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC50 values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.
PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION
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Page/Page column 6; 10, (2009/04/24)
The present invention is directed to a process for preparing compounds of formula (I): wherein A, R1-R3, X, s, t, u, m and Z are defined herein, comprising the step of reacting a reagent of formula (II): in the presence of Pd(O) meta
Synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions
Wang, Yanong D.,Dutia, Minu,Floyd, M. Brawner,Prashad, Amar S.,Berger, Dan,Lin, Melissa
experimental part, p. 57 - 61 (2009/04/11)
A regio- and stereoselective synthesis of 7-(E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated coupling reactions was developed. The comparison and optimization of stereoselectivity of the Heck, Stille, and Suzuki reactions of 7-bromo or 7-trifl
