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946497-94-5

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946497-94-5 Usage

General Description

Tert-butyl 4-cyano-2,2-dimethyl-3-oxopyrrolidine-1-carboxylate is a chemical compound with the molecular formula C11H18N2O3. It is a derivative of pyrrolidine, a heterocyclic organic compound, and contains a tert-butyl and cyano group attached to the pyrrolidine ring. tert-butyl 4-cyano-2,2-dimethyl-3-oxopyrrolidine-1-carboxylate is commonly used in organic synthesis as a building block for the preparation of pharmaceuticals and other fine chemicals. It is also used as a reagent in the synthesis of various compounds due to its stable and reactive nature. Additionally, it can be used as a starting material for the production of agrochemicals and other specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 946497-94-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,4,9 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 946497-94:
(8*9)+(7*4)+(6*6)+(5*4)+(4*9)+(3*7)+(2*9)+(1*4)=235
235 % 10 = 5
So 946497-94-5 is a valid CAS Registry Number.

946497-94-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Pyrrolidinecarboxylic acid, 4-cyano-2,2-dimethyl-3-oxo-, 1,1-dimethylethyl ester

1.2 Other means of identification

Product number -
Other names TERT-BUTYL 4-CYANO-2,2-DIMETHYL-3-OXOPYRROLIDINE-1-CARBOXYLATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:946497-94-5 SDS

946497-94-5Relevant articles and documents

Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors

Cheng, Maosheng,Liu, Nian,Lv, Ruicheng,Qin, Qiaohua,Sun, Yin,Sun, Yixiang,Wang, Ruifeng,Wang, Xiaoyan,Wu, Tianxiao,Yin, Wenbo,Zhang, Chu,Zhao, Dongmei

, (2021/06/28)

The tropomyosin receptor kinases TRKs are responsible for different tumor types which caused by NTRK gene fusion, and have been identified as a successful target for anticancer therapeutics. Herein, we report a potent and selectivity TRKs inhibitor 19m through rational drug design strategy from a micromolar potency hit 17a. Compound 19m significantly inhibits the proliferation of TRK-dependent cell lines (Km-12), while it has no inhibitory effect on TRK-independent cell lines (A549 and THLE-2). Furthermore, kinases selectivity profiling showed that in addition to TRKs, compound 19m only displayed relatively strong inhibitory activity on ALK. These data may indicate that compound 19m has a good drug safety. Partial ADME properties were evaluated in vitro and in vivo. Compound 19m exhibited a good AUC values and volume of distribution and low clearance in the pharmacokinetics experiment of rats. Finally, a pharmacophore model guided by experimental results is proposed. We hope this theoretical model can help researchers find type I TRK inhibitors more efficiently.

TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS

-

, (2013/07/05)

The present invention provides compounds of Formula (I) as M1 receptor positive allosteric modulators for the treatment of diseases mediated by the muscarinic M1 mediator.

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors

Li, Hui,Hong, Yufeng,Nukui, Seiji,Lou, Jihong,Johnson, Sarah,Scales, Stephanie,Botrous, Iriny,Tompkins, Eileen,Yin, Chunfeng,Zhou, Ru,He, Mingying,Jensen, Jordan,Bouzida, Djamal,Alton, Gordon,Lafontaine, Jennifer,Grant, Stephan

scheme or table, p. 584 - 587 (2011/02/27)

A novel series of pyrrolopyrazole-based protein kinase C β II inhibitors has been identified from high-throughput screening. Herein, we report our initial structure-activity relationship studies with a focus on optimizing compound ligand efficiency and physicochemical properties, which has led to potent inhibitors with good cell permeability.

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