946575-24-2Relevant academic research and scientific papers
Cyclic benzamidines as orally efficacious NR2B-selective NMDA receptor antagonists
Nguyen, Kevin T.,Claiborne, Christopher F.,McCauley, John A.,Libby, Brian E.,Claremon, David A.,Bednar, Rodney A.,Mosser, Scott D.,Gaul, Stanley L.,Connolly, Thomas M.,Condra, Cindra L.,Bednar, Bohumil,Stump, Gary L.,Lynch, Joseph J.,Koblan, Kenneth S.,Liverton, Nigel J.
, p. 3997 - 4000 (2008/02/10)
A novel series of cyclic benzamidines was synthesized and shown to exhibit NR2B-subtype selective NMDA antagonist activity. Compound 29 is orally active in a carrageenan-induced rat hyperalgesia model of pain.
