94662-52-9

Upstream product

• 114033-51-1 N-<3-<3-(diethoxymethyl)phenoxy>propyl>thieno<3,4-d>isothiazol-3-amine 1,1-dioxide 
• 73279-35-3 2-<3-<3-(1,3-dioxolan-2-yl)phenoxy>propyl>-1H-isoindole-1,3(2H)-dione 
• 114033-50-0 3-<3-(diethoxymethyl)phenoxy>propanamine 
• 94662-48-3 thieno[3,4-d]isothiazole-3(2H)-thione 1,1-dioxide 
• 94662-49-4 3-(methylthio)thieno<3,4-d>isothiazole 1,1-dioxide 
• 73279-04-6 3-[1-piperidinylmethyl]phenol 
• 59337-79-0 thieno(3,4-d)-1,2-thiazol-3(2H)-one 1,1-dioxide 
• 114033-47-5 {3-[3-(3,6-Dihydro-2H-pyridin-1-ylmethyl)-phenoxy]-propyl}-(1,1-dioxo-1H-1λ⁶-thieno[3,4-d]isothiazol-3-yl)-amine 
• 102244-43-9 1-<<3-(3-bromopropoxy)phenyl>methyl>piperidine 
• 114033-53-3 thieno<3,4-d>isothiazol-3-amine 1,1-dioxide 
• 110-89-4 piperidine 
• 114033-48-6 3-<3-(thieno<3,4-d>isothiazol-3-ylamino)propoxy>benzaldehyde S',S'-dioxide 

Relevant academic research and scientific papers

Syntheses and Gastric Acid Antisecretory Properties of the H2-Receptor Antagonist N-propyl>thienoisothiazol-3-amine 1,1-Dioxide and Related Derivatives

The synthesis and gastric acid antisecretory properties of several N-substituted thienoisothiazol-3-amine 1,1-dioxides and analogues are described.Two of the more potent compounds, N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6a) and N-propyl>thienoisothiazol-3-amine 1,1-dioxide (6b), showed greater potencies as H2-receptor antagonist (in vitro) than ranitidine.They also had potent gastric acid antisecretory activities in vivo, inhibiting basal acid secretion in the rat (6a, 6b), histamine-stimulated acid secretion in the dog (6a, 6b), and food-stimulated acid secretion in the dog (6a).These were selected for further pharmacological evaluation.

Precursors of benzo- and thieno-fused heterocyclic anti-ulcer agents

A process for preparing certain benzo- and thieno-fused heterocyclic compounds having H2 -receptor antagonist and antisecretory activity, which comprises the amide reduction of N-substituted carbamoyl-containing benzo- or thieno-fused heterocyc