946714-14-3 Usage
Uses
Used in Pharmaceutical and Agrochemical Synthesis:
(2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE is used as a building block for the synthesis of pharmaceuticals and agrochemicals. Its unique structure allows for the development of new compounds with potential therapeutic and pesticidal properties.
Used in Biological Research:
As a fluorescent probe, (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE is utilized in biological research to study various cellular processes and interactions. Its fluorescence properties enable researchers to track and visualize specific biomolecules within living cells.
Used in Polymer Production:
(2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE serves as a stabilizer in the production of polymers, enhancing their stability and performance. Its presence can improve the durability and resistance of polymer materials against environmental factors.
Used in Aromatic Compound Synthesis:
As a starting material, (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE is employed in the synthesis of various aromatic compounds. Its reactivity and structural features make it a valuable precursor for creating a wide range of aromatic molecules for different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 946714-14-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,6,7,1 and 4 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 946714-14:
(8*9)+(7*4)+(6*6)+(5*7)+(4*1)+(3*4)+(2*1)+(1*4)=193
193 % 10 = 3
So 946714-14-3 is a valid CAS Registry Number.
946714-14-3Relevant academic research and scientific papers
Kim, Youngjae,Tae, Jinsung,Lee, Kangho,Rhim, Hyewhon,Choo, Il Han,Cho, Heeyeong,Park, Woo-Kyu,Keum, Gyochang,Choo, Hyunah
, p. 4587 - 4596 (2014)
5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.
