946714-14-3

Basic information

• Product Name: (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE
• Synonyms: (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE
• CAS NO: 946714-14-3
• Molecular Formula: C13H12FN
• Molecular Weight: 201.2394832
• Mol File: 946714-14-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(946714-14-3)
• EPA Substance Registry System: (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE(946714-14-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 946714-14-3(Hazardous Substances Data)

Usage

General Description

The chemical (2'-fluoro[1,1'-biphenyl]-2-yl)methanamine, also known as 2-Fluorobenzophenone, is a compound with the molecular formula C13H10F. It is a benzophenone derivative that contains a fluorine substituent at the 2-position of the biphenyl ring. (2'-FLUORO[1,1'-BIPHENYL]-2-YL)METHANAMINE is used in a variety of applications, including as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as a fluorescent probe in biological research and as a stabilizer in the production of polymers. Additionally, it is used as a starting material for the synthesis of various aromatic compounds. Overall, (2'-fluoro[1,1'-biphenyl]-2-yl)methanamine is a versatile chemical with diverse uses in industry and research.

Upstream product

• 4387-36-4 2-iodobenzonitrile 
• 1993-03-9 o-fluorophenylboronic acid 
• 400820-15-7 2'-fluoro-[1,1'-biphenyl]-2-carbonitrile 

Relevant articles and documents

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression

5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.