946822-70-4Relevant academic research and scientific papers
Identification of novel, potent and selective inhibitors of Polo-like kinase 1
Chen, Shaoqing,Bartkovitz, David,Cai, Jianping,Chen, Yi,Chen, Zhi,Chu, Xin-Jie,Le, Kang,Le, Nam T.,Luk, Kin-Chun,Mischke, Steve,Naderi-Oboodi, Goli,Boylan, John F.,Nevins, Tom,Qing, Weiguo,Chen, Yingsi,Wovkulich, Peter M.
, p. 1247 - 1250 (2012/03/26)
A series of pyrimidodiazepines was identified as potent Polo-like kinase 1 (PLK1) inhibitors. The synthesis and SAR are discussed. The lead compound 7 (RO3280) has potent inhibitory activity against PLK1, good selectivity against other kinases, and excell
SUBSTITUTED PYRIMIDODIAZEPINES
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Page/Page column 12, (2008/12/08)
The present invention provides PLK1 inhibitor compounds of formula I: Useful in the treatment or control of cell proliferative disorders, particularly oncological disorders. These compounds and formulations containing such compounds may be useful in the t
Dihydrodiazepines useful as inhibitors of protein kinases
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Page/Page column 63, (2008/12/06)
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, co
