946847-91-2Relevant academic research and scientific papers
Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via 'click chemistry'
Chen, Jianyong,Nikolovska-Coleska, Zaneta,Yang, Chao-Yie,Gomez, Cindy,Gao, Wei,Krajewski, Krzysztof,Jiang, Sheng,Roller, Peter,Wang, Shaomeng
, p. 3939 - 3942 (2007)
STAT3 is a promising molecular target for the design of new anticancer drugs. In this paper, we report the design and synthesis of a conformationally constrained macrocyclic peptidomimetic 2 via click chemistry. Compound 2 was determined to bind to STAT3
