946851-45-2Relevant academic research and scientific papers
Concise total synthesis of the thiazolyl peptide antibiotic GE2270 A
Delgado, Oscar,Martin Mueller,Bach, Thorsten
experimental part, p. 2322 - 2339 (2009/04/10)
The potent antibiotic thiazolylpeptide GE2270 A was synthesized starting from N-tert-butyloxycarbonyl protected valine in a longest linear sequence of 20 steps and with an overall yield of 4.8 %. Key strategy was the assembly of the 2,3,6-trisubstituted p
Total synthesis of the thiazolyl peptide GE2270 A
Mueller, H. Martin,Delgado, Oscar,Bach, Thorsten
, p. 4771 - 4774 (2008/02/10)
(Chemical Equation Presented) When one door closes, another opens: In the synthesis of the thiazolyl peptide GE2270 A (1), the bonds labeled I and II at the pyridine core were established by two consecutive cross-coupling reactions. Amide bond formation (
