946852-96-6Relevant articles and documents
Isolation of high-affinity trypsin inhibitors from a DNA-encoded chemical library
Melkko, Samu,Zhang, Yixin,Dumelin, Christoph E.,Scheuermann, Joerg,Neri, Dario
, p. 4671 - 4674 (2007)
(Chemical Equation Presented) Maturing is easy to do: Annealing benzamidine-oligonucleotide conjugates with a library of DNA-encoded compounds allows the affinity capture of pharmacophores that are capable of binding to exosites adjacent to the primary substrate-binding pocket of the serine protease trypsin. Selected conjugates show an improvement in IC50 values of several orders of magnitude compared with the starting benzamidine.
An efficient metal catalyst free approach to synthesize 5-(4-(1,2,4,5 tetrazin-3-yl)benzylamino)-5-oxopentanoic acid
Zewde, Berhanu,Atoyebi, Olufolasade,Raghavan, Dharmaraj
supporting information, p. 3100 - 3103 (2018/07/13)
Despite the wide use of 1,2,4,5- tetrazines in biomaterials and materials science, currently there does not exist synthetic method(s) that can yield significant amount of 1,2,4,5- tetrazines without the use of potentially toxic metal catalysts. Here, we report a less energy intensive and more efficient metal catalyst free approach for the synthesis of an asymmetric tetrazine. A range of operating parameters such as extraction pH and temperature were regulated to achieve a practical yield nearly 1.5 times greater than the yields reported in the literature for similar synthetic procedures.
Synthetically tractable click hydrogels for three-dimensional cell culture formed using tetrazine-norbornene chemistry
Alge, Daniel L.,Azagarsamy, Malar A.,Donohue, Dillon F.,Anseth, Kristi S.
, p. 949 - 953 (2013/05/21)
The implementation of bio-orthogonal click chemistries is a topic of growing importance in the field of biomaterials, as it is enabling the development of increasingly complex hydrogel materials capable of providing dynamic, cell-instructive microenvironm
