946855-77-2

Basic information

• Product Name: 4,6-dichloro-5-[(E)-2-(4-phenyl)diazenyl]-2-(propylsulfanyl)pyrimidine
• CAS NO: 946855-77-2
• Molecular Weight: 327.237
• Mol File: 946855-77-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4,6-dichloro-5-[(E)-2-(4-phenyl)diazenyl]-2-(propylsulfanyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-dichloro-5-[(E)-2-(4-phenyl)diazenyl]-2-(propylsulfanyl)pyrimidine(946855-77-2)
• EPA Substance Registry System: 4,6-dichloro-5-[(E)-2-(4-phenyl)diazenyl]-2-(propylsulfanyl)pyrimidine(946855-77-2)

Safety Data

• Hazardous Substances Data: 946855-77-2(Hazardous Substances Data)

Upstream product

• 145783-12-6 4,6-dihydroxy-2-(propylsulfanyl)pyrimidine 

Downstream Products

• 1402150-32-6 (1S 2S,3R,5S)-3-[(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol 

Relevant articles and documents

A [...] preparation method and intermediate

The present invention relates to a preparation method and an intermediate of ticagrelor. The preparation method comprises that a compound represented by a formula VIII and a compound represented by a formula VII or a salt thereof as raw materials to carry out a reaction, and the obtained intermediate is subjected to acetonylidene protection group removing, optionally substituted azobenzene protection group removing, and cyclization, and then reacts with a compound represented by a formula II or a salt thereof to prepare the ticagrelor. The preparation method of the present invention has characteristics of short step, high total yield, mild reaction conditions and simple post-treatment, and is suitable for industrial production.