946860-67-9Relevant academic research and scientific papers
Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent γ-secretase inhibitors
Yang, Michael G.,Shi, Jian-Liang,Modi, Dilip P.,Wells, Jennifer,Cochran, Brian M.,Wolf, Mark A.,Thompson, Lorin A.,Ramanjulu, Mercy M.,Roach, Arthur H.,Zaczek, Robert,Robertson, David W.,Wexler, Ruth R.,Olson, Richard E.
, p. 3910 - 3915 (2008/02/07)
We report the synthesis of benzoazepine-derived cyclic malonamides (2) and aminoamides (3) as γ-secretase inhibitors for the potential treatment of Alzheimer's disease. The in vitro structure-activity relationships of 2 and 3 along with dog pharmacokineti
