94716-94-6

Basic information

• Product Name: ALPHA-HEMOLYSIN
• Synonyms: ALPHA-TOXIN, STAPHYLOCOCCUS AUREUS;A-HEMOLYSIN FROM STAPHYLOCOCCUS AUREUS;α-hemolysin from staphylococcus aureus;ALPHA-HEMOLYSIN (STAPHYLOCOCCUS AUREUS));α-HeMolysin;STAPHYLOCOCCUS AUREUS;ALPHA-HEMOLYSIN;ALPHA-TOXIN
• CAS NO: 94716-94-6
• Molecular Formula: C₃₆H₂₀N₇Na₅O₁₈S₅
• Molecular Weight: 1113.85395
• Product Categories: Biochemicals and Reagents;Protein Extracts;Proteins and Derivatives
• Mol File: 94716-94-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble0.49 - 0.51mg/mL
• CAS DataBase Reference: ALPHA-HEMOLYSIN(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-HEMOLYSIN(94716-94-6)
• EPA Substance Registry System: ALPHA-HEMOLYSIN(94716-94-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-21/22
• Safety Statements: 36-36/37
• WGK Germany: 3
• Hazardous Substances Data: 94716-94-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 94716-94-6 differently. You can refer to the following data:
1. ALPHA-HEMOLYSIN was used in a study to test the efflux pump and haemolysin activity of Escherichia coli of dairy origin. It was also used to test its adaptation to benzalkonium chloride and the effect of ciprofloxacin on biofilm formation.
2. α-Hemolysin was used in a study to test the efflux pump and haemolysin activity of Escherichia coli of dairy origin. It was also used to test its adaptation to benzalkonium chloride and the effect of ciprofloxacin on biofilm formation.

General Description

α-Hemolysin, a pore-forming cytotoxin is an extracellular protein secreted by most strains of pathogenic?Staphylococcus aureus. It is secreted as a water-soluble monomer and is a small β-barrel protein.

Biochem/physiol Actions

α-Hemolysin is selectively hemolytic and the monomeric form binds to a membrane and specific receptors are not required for binding. Upon binding to biological membranes and/or artificial membranes, self-oligomerization occurs, resulting in ring structures (hexameric aggregates) believed to represent transmembrane pores, which are permeable to ions and small metabolites. It has a marked preference for rabbit red blood cells. α-hemolysin stimulates cellular phospholipases and induces a Ca2+?influx. It leads to membrane disruption of the endothelial barrier and leakage of cytoplasmic components and osmotic lysis of the cells. α-hemolysin is implicated in the pathogenesis of sepsis.