947166-01-0Relevant academic research and scientific papers
Dimeric bisbenzimidazoles inhibit the DNA methylation catalyzed by the murine Dnmt3a catalytic domain
Cherepanova,Ivanov,Maltseva,Minero,Gromyko,Streltsov,Zhuze,Gromova
scheme or table, p. 295 - 300 (2011/10/31)
When located in the DNA minor groove, dimeric bisbenzimidazoles DB(n) effectively inhibited in vitro the Dnmt3a catalytic domain (IC50 5-77 μM). The lowest IC50 value was observed for compound DB(11) with an 11-unit methylene linker joining the bisbenzimidazole fragments. Increased time of incubation of DNA with DB(n) as well as the presence of AT-clusters in DNA enhances the inhibitory effect.
