947175-17-9

Basic information

• Product Name: 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid
• Synonyms: 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid;(2S,3S,4S,5R,6S)-6-(6-Chloro-4-methyl-2-oxo-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid;6-Chloro-4-methylumbelliferyl 2-D-glucopyranosiduronic Acid
• CAS NO: 947175-17-9
• Molecular Formula: C16H15ClO9
• Molecular Weight: 386.7379
• Mol File: 947175-17-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid(947175-17-9)
• EPA Substance Registry System: 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid(947175-17-9)

Safety Data

• Hazardous Substances Data: 947175-17-9(Hazardous Substances Data)

Usage

Description

6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid, also known as 6-CMUG, is a fluorogenic substrate commonly used in biochemical assays. It is structurally derived from a benzopyran core with a chloro and methyl group substitution, and features a glucopyranosiduronic acid moiety attached to the 7-position. 6-Chloro-4-methyl-2-oxo-2H-1-benzopyran-7-yl beta-D-glucopyranosiduronic acid exhibits unique fluorescent properties upon enzymatic cleavage, making it a valuable tool in various analytical applications.

Uses

Used in Clinical Diagnostics:
6-CMUG is utilized as a fluorogenic substrate for the β-glucosidase assay, which is instrumental in monitoring the hydrolysis of glycosidic bonds by β-glucosidase enzymes. This enzymatic activity has clinical applications for investigating Gaucher's disease, a genetic disorder characterized by the accumulation of glucocerebroside in macrophages.
Used in High-Throughput Screening:
The unique fluorescent properties of 6-CMUG make it a potentially useful compound in high-throughput screening applications. Its ability to fluoresce upon enzymatic cleavage allows for sensitive and quantitative detection of enzymatic activity, which can be applied in various research and diagnostic settings.
Used in Metagenomic Screening:
6-CMUG may also find utility in metagenomic screening, where novel fluorogenic substrates are needed for sensitive detection of specific enzymatic activities. This can aid in the identification and characterization of microorganisms within complex environmental samples, contributing to our understanding of microbial diversity and function.