947249-01-6

Basic information

• Product Name: 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester
• Synonyms: 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester;5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-trifluoromethyl)pyridin-2-amine;3-(trifluoroMethyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-aMine;6-Amino-5-(trifluoromethyl)pyridine-3-boronic acid pinacol ester;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (6-amino-5-(trifluoromethyl)pyridin-3-yl)boronate
• CAS NO: 947249-01-6
• Molecular Formula: C₁₂H₁₆BF₃N₂O₂
• Molecular Weight: 306.0891296
• Mol File: 947249-01-6.mol
• Article Data: 14

Chemical Properties

• Melting Point: 132-134℃
• Boiling Point: 359.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.23
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.31±0.50(Predicted)
• CAS DataBase Reference: 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester(947249-01-6)
• EPA Substance Registry System: 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester(947249-01-6)

Safety Data

• Hazardous Substances Data: 947249-01-6(Hazardous Substances Data)

Usage

General Description

2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester is a chemical compound with a boronic acid functional group and a trifluoromethylpyridine group. It is often used in organic synthesis as a reagent for the preparation of various pharmaceuticals and agrochemicals. 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester is typically employed in Suzuki-Miyaura coupling reactions, which are key processes in the formation of carbon-carbon bonds. Additionally, its pinacol ester form enhances its stability and solubility, making it easier to handle and use in reactions. Its unique structure and functional groups make it a valuable tool in the field of organic chemistry, particularly in the development of new drugs and agricultural compounds.

Upstream product

• 183610-70-0 2-amino-3-trifluoromethylpyridine 
• 79456-34-1 5-bromo-3-(trifluoromethyl)pyridin-2-amine 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 1083429-59-7 N-(2-{4-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-ethyl)-4-morpholin-4-yl-benzamide 
• 1083429-55-3 1-(3-{5-[3-(6-amino-5-trifluoromethyl-pyridin-3-yl)-2-methyl-imidazo[1,2-b]pyridazin-6-yl]-2-methoxy-phenoxy}-propyl)-3-(3-methoxy-phenyl)-urea 
• 1083430-94-7 C₂₈H₃₁F₃N₆O₄ 
• 1083430-95-8 5-{6-[3-(3-amino-propoxy)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine 
• 1083428-92-5 5-{6-[4-(2-amino-ethoxy)-3-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-3-yl}-3-trifluoromethyl-pyridin-2-ylamine 
• 1084951-43-8 5-(3-(6-(4-phenylthiazol-2-ylamino)pyridin-3-yl)imidazo[1,2-b]pyridazin-6-yl)-3-trifluoromethylpyridin-2-ylamine 
• 1084951-48-3 5-(3-(4-ethanesulfonylphenyl)imidazo[1,2-b]pyridazin-6-yl)-3-trifluoromethylpyridin-2-ylamine 
• 1366050-29-4 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1366047-63-3 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]quinoxalin-1-yl)phenyl)-2-methylpropanenitrile 
• 1360177-17-8 4-[5-(6-amino-5-trifluoromethyl-pyridin-3-yl)-imidazo[2,1-b][1,3,4]thiadiazol-2-ylamino]-cyclohexanone 

Relevant articles and documents

Fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834

A practical fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 (1) was developed. The key C[sbnd]C bond was constructed via a Suzuki–Miyaura cross-coupling of iodopyrazole 2 and pyridine boronic ester 3 to afford ketone 12. Su

PROCESS FOR THE PREPARATION OF SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE COMPOUNDS, INTERMEDIATES AND POLYMORPHS THEREOF

The present invention relates to a process for preparation of substituted imidazo[4,5- c]quinoline compounds (the compounds of formula I as described) and intermediates thereof. The present invention also relates to polymorphs of a compound encompassed in the compound of formula I and their use in the treatment of proliferative disorders, particularly cancers.

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K

PI3 kinases are a family of lipid kinases mediating numerous cell processes such as proliferation, migration and differentiation. The PI3 Kinase pathway is often de-regulated in cancer through PI3Kα overexpression, gene amplification, mutations and PTEN p