947321-01-9Relevant academic research and scientific papers
Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
Rueeger, Heinrich,Rondeau, Jean-Michel,McCarthy, Clive,M?bitz, Henrik,Tintelnot-Blomley, Marina,Neumann, Ulf,Desrayaud, Sandrine
, p. 1942 - 1947 (2011/04/24)
This Letter describes the de novo design of non-peptidic hydroxyethylamine (HEA) inhibitors of BACE-1 by elimination of P-gp contributing amide attachments. The predicted binding mode of the novel cyclic sulfone HEA core template was confirmed in a X-ray
