947535-80-0Relevant academic research and scientific papers
One-pot, three-component Mannich-type reaction catalyzed by functionalized ionic liquid
Fang, Dong,Gong, Kai,Zhang, Dai-Zhen,Liu, Zu-Liang
, p. 1325 - 1329 (2009)
A three-component Mannich-type reaction of aromatic aldehydes, aromatic amines, and ketones was catalyzed by a novel functionalized ionic liquid, 3-(N,N-dimethyldodecylammonium)propanesulfonic acid hydrogen sulfate ([DDPA][HSO4]) at room temperature to give various β-amino carbonyl compounds in good yields. The catalyst could be reused at least six times without noticeably reducing catalytic activity.
Synthesis of [beta]-amino ketone compounds through catalysis by bifunctional ionic liquid
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Paragraph 0033; 0034, (2017/05/18)
The invention discloses a synthesis method of [beta]-amino ketone compounds through catalysis by a bifunctional ionic liquid. A key of the technical scheme is that the bifunctional ionic liquid having bifunctional groups of Bronsted acid and Lewis acid is employed as a catalyst while water/ethanol are employed as a reaction medium. Raw materials, including aromatic aldehyde, ketone and aromatic amine, are subjected to a reaction at normal temperature and under normal pressure to obtain a target product. The synthesis method has the advantages of: 1) the raw materials are widely-sourced and the compounds are easy to prepare; 2) the catalyst has bifunctional groups, wherein the Bronsted acid and the Lewis acid in the molecule achieve synergistic catalysis, and the catalyst can be recycled, thereby achieving significant energy-saving and emission-reducing effects; and 3) the synthesis method is carried out with the water/ethanol as the reaction medium, so that the method has safe and stable reactions, is easy to industrially amplify and is an environment-friendly chemical engineering process.
