947546-07-8Relevant academic research and scientific papers
PtCl2-catalyzed hydrative cyclization of trialkyne functionalities to form bicyclic spiro ketones
Chang, Hsu-Kai,Datta, Swarup,Das, Arindam,Odedra, Arjan,Liu, Rai-Shung
, p. 4744 - 4747 (2008/02/08)
(Chemical Equation Presented) Triple rounds: A regioselective hydrative cyclization of triynes has been developed to give bicyclic β-hydroxy spiro ketones, which undergo subsequent dehydration to give the β,γ- unsaturated ketones (see scheme). Model reactions suggest that this platinum catalysis includes two selective hydrations, an alkyne insertion, and an aldol condensation.
