947600-05-7

Basic information

• Product Name: N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel
• Synonyms: N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel
• CAS NO: 947600-05-7
• Molecular Weight: 1176.68
• Mol File: 947600-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel(CAS DataBase Reference)
• NIST Chemistry Reference: N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel(947600-05-7)
• EPA Substance Registry System: N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]-7,10-di(2,2,2-trichloroethyloxycarbonyl)-docetaxel(947600-05-7)

Safety Data

• Hazardous Substances Data: 947600-05-7(Hazardous Substances Data)

Upstream product

• 912272-00-5 C₅H₈ClFO₂ 
• 114915-16-1 10-deacetyl-7,10-diTroc-baccatin III 

Downstream Products

• 947600-16-0 N-de-tert-butoxycarbonyl-N-[2-(1-fluoro-2-methyl)-propyloxycarbonyl]docetaxel 

Relevant articles and documents

Design, synthesis and biological evaluation of novel fluorinated docetaxel analogues

A series of novel fluorinated docetaxel analogues have been synthesized and evaluated in vitro and in vivo. Incorporated one, two or three fluorine atom(s) either at both meta position on C-2 benzolate and 3′-N-tert-butyloxyl group or only at 3′-N-tert-butyloxyl group has resulted in potent analogues which have comparable or superior in vitro and in vivo cytotoxicity to docetaxel. Among them, compounds 14d and 14e have displayed more potent cytotoxicity than docetaxel both in human cancer cell line SK-OV-3 in vitro and in human non-small cell lung cancer A549 xenografts in vivo. Preliminary data show that compound 14a has reduced acute animal toxicity in mice compared with docetaxel.