947674-87-5 Usage
General Description
N-[(1R)-2,3-Dihydro-6-hydroxy-1H-inden-1-yl]carbamic acid tert-butyl ester is a chemical compound with the molecular formula C14H21NO4. It is a carbamic acid ester, which means it is a derivative of carbamic acid containing a tert-butyl group. The compound has a 1R configuration and a 2,3-dihydro-6-hydroxy-1H-inden-1-yl group, which gives it certain biological and pharmacological properties. It may have potential uses in pharmaceuticals, particularly in the development of new drugs targeting specific biological pathways. The compound's structure and properties make it an interesting subject for further research and potential applications in the fields of medicine and pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 947674-87-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,7,6,7 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 947674-87:
(8*9)+(7*4)+(6*7)+(5*6)+(4*7)+(3*4)+(2*8)+(1*7)=235
235 % 10 = 5
So 947674-87-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO3/c1-14(2,3)18-13(17)15-12-7-5-9-4-6-10(16)8-11(9)12/h4,6,8,12,16H,5,7H2,1-3H3,(H,15,17)/t12-/m1/s1
947674-87-5Relevant articles and documents
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors
Jaime-Figueroa, Saul,De Vicente, Javier,Hermann, Johannes,Jahangir, Alam,Jin, Sue,Kuglstatter, Andreas,Lynch, Stephen M.,Menke, John,Niu, Linghao,Patel, Vaishali,Shao, Ada,Soth, Michael,Vu, Minh Diem,Yee, Calvin
supporting information, p. 2522 - 2526 (2013/06/26)
We report the discovery of a novel series of ATP-competitive Janus kinase 3 (JAK3) inhibitors based on the 5H-pyrrolo[2,3-b]pyrazine scaffold. The initial leads in this series, compounds 1a and 1h, showed promising potencies, but a lack of selectivity against other isoforms in the JAK family. Computational and crystallographic analysis suggested that the phenyl ether moiety possessed a favorable vector to achieve selectivity. Exploration of this vector resulted in the identification of 12b and 12d, as potent JAK3 inhibitors, demonstrating improved JAK family and kinase selectivity.
