947682-10-2

Upstream product

• 947682-08-8 (+)-(1R,2S,5S)-3-benzyl-7-methyl-2-phenyl-9-oxa-3,7-diazabicyclo[3.3.1]nonane 
• 947682-06-6 (-)-(2S,3S,6R)-4-benzyl-2,6-bis(methanesulfonyloxymethyl)-3-phenylmorpholine 
• 98819-68-2 3-phenyl-(2R,3R)-oxiran-2-ylmethanol 
• 93027-52-2 (+)-(2S,3S)-3-(benzylamino)-3-phenylpropane-1,2-diol 

Relevant academic research and scientific papers

Chiral 2-endo-substituted 9-oxabispidines: Novel ligands for enantioselective copper(ii)-catalyzed henry reactions

A flexible approach, applicable on a gram scale, to chiral 2-endosubstituted 9-oxabispidines was developed. The key intermediate, a cis-configured 6-aminomethylmorpholine-2carbonitrile, was prepared from (R)-3aminopropane-1,2-diol and 2-chloroacrylonitril

A flexible route to chiral 2-endo-substituted 9-oxabispidines and their application in the enantioselective oxidation of secondary alcohols

A new and flexible route to enantiomerically pure bi-and tricyclic 9-oxabispidines has been developed with use of (1R,5S)-7-methyl-2-oxo-9-oxa-3,7- diazabicyclo[33.1]nonane-3-carboxylic acid tert-butyl ester as the common late-stage intermediate. The 9-oxabispidines synthesized were evaluated as the chiral ligands in the Pd(II)-catalyzed oxidative kinetic resolution of secondary alcohols giving good to excellent selectivity factors of up to 19.

Enantioselective synthesis of 2-phenyl-9-oxabispidines

A small selection of enantiomerically pure 2-phenyl-9-oxabispidines was synthesized in a three to five step procedure from commercially available starting materials. Ring opening of (R,R)-3-phenylglycidol with benzylamine, condensation with (S)-epichloroh