947683-08-1Relevant articles and documents
Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides
Elenkov, Maja Majeric,Tang, Lixia,Meetsma, Auke,Hauer, Bernhard,Janssen, Dick B.
, p. 2417 - 2420 (2008)
(Chemical Equation Presented) Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69-98% ee). This is the first example of the biocatalytic conversion of a range of epoxides to the corresponding oxazolidinones.