947740-31-0Relevant academic research and scientific papers
The application of a recyclable organocatalytic system to the asymmetric domino Michael/Henry reaction in aqueous media
Chintala, Poornima,Ghosh, Subrata K.,Long, Elizabeth,Headley, Allan D.,Ni, Bukuo
supporting information; experimental part, p. 2905 - 2909 (2012/01/02)
A new type of pyrrolidine-based organocatalyst has been developed and found to be very effective for the domino Michael/Henry reaction in aqueous solvents. For the reaction involving pentane-1,5-dial and various nitroolefins, good yields (65-85%) and exce
Diphenylprolinol silyl ether as a catalyst in an enantioselective, catalytic, tandem Michael/Henry reaction for the control of four stereocenters
Hayashi, Yujiro,Okano, Tsubasa,Aratake, Seiji,Hazelard, Damien
, p. 4922 - 4925 (2008/02/08)
(Chemical Equation Presented) A choice of three: The tandem Michael/ Henry reaction of a nitroalkene and pentane-1,5-dial (generated in situ) proceeded efficiently when diphenylprolinol silyl ether was used as an organocatalyst to afford substituted nitrocyclohexanecarbaldehydes with high diastereo- and enantioselectivity (see scheme; TMS: trimethylsilyl). Isomerization under basic or acidic conditions diastereoselectively converts the product into two stereoisomers, without compromising the enantioselectivity.
