94775-24-3

Upstream product

• 27349-48-0 3-methyl-5-(2-phenylethyl)isoxazole 
• 59-88-1 phenylhydrazine hydrochloride 
• 114042-90-9 (Z)-5-Amino-1-phenyl-hex-4-en-3-one 

Relevant academic research and scientific papers

Scope and limitations in the regioselective synthesis of 1,3,5-trisubstituted pyrazoles from β-amino enones and hydrazine derivatives. 13C-chemical shift prediction rules for 1,3,5-trisubstituted pyrazoles

β-amino enones react with hydrazine derivatives to give regioselectively 1,3,5-trisubstituted pyrazoles. The synthetic method only presents limitations when the β-substituent of the enone and the hydrazine substituent are bulky or possess an electron withdrawing character. Comparison of the 13C-NMR spectra of the seventy pyrazoles allowed us to estimate a 13C-chemical shift prediction rule for 1,3,5-trisubstituted pyrazoles, with deviations of less than ± 1 ppm.

Regiospecific Synthesis of 1-Arylpyrazoles

A new regiospecific synthesis of 1-aryl-substituted pyrazoles by reaction of aryl-hydrazines with β-aminoenones is reported.