948026-76-4Relevant academic research and scientific papers
Synthesis of enantiopure 1-azaspiro[4.5]decanes by iodoaminocyclization of allylaminocyclohexanes
Diaba, Faiza,Puigbo, Gemma,Bonjoch, Josep
, p. 3038 - 3044 (2007)
The 5-endo iodine-promoted ring closure of 4-allyl-4-(alkylamino) cyclohexanone derivatives gives the corresponding 1-azaspiro[4.5]decanes in good yields. The reaction was tested with enantiopure homoallylamines to evaluate the diastereoselectivity of the process and to provide a route for possible intermediates to the natural products embodying this azabicyclic ring. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
