94806-12-9Relevant academic research and scientific papers
Scandium(III) triflate mediated intramolecular ring expansion of aziridines: A direct access to 4-aryltetrahydroisoquinolines
Satyanarayana, Tummanapalli,Muthuraman, Parthasarathy,Vangapandu, Dhanunjaya Naidu,Majumder, Supriyo
, p. 6787 - 6790 (2015/01/08)
A novel, high yielding facile synthesis of 4-substituted tetrahydroisoquinolines has been developed by employing scandium(III) triflate mediated intramolecular ring expansion of aziridines. The meta-substituted electron-donating group on the benzene ring facilitates trapping of an in situ generated benzyl carbenium ion cation leading to the formation of tetrahydroisoquinolines.
ARYL, HETEROARYL, AND HETEROCYCLE SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF
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Page/Page column 92, (2010/12/17)
Novel aryl, heteroaryl, and non-aromatic heterocyle substituted tetrahydroisoquinolines are described in the present invention. These compounds are used in the treatment of various neurological and physiological disorders. Methods of making these compounds are also described in the present invention.
